It happened around 12 a.m. ET in the 5000 block of Killam Avenue, the Norfolk Police Department tweeted.
Of the seven people rushed to a nearby hospital, two had life-threatening injuries and five others had non-life-threatening wounds, police said.
Authorities did not release any information about a possible motive nor suspect.
Norfolk State University said some of the victims are students at the university, but did not specify how many.
“Norfolk Police have informed us that several NSU students have been the victims of a shooting at an isolated off-campus location near 50th Street and Hampton Blvd,” the university tweeted.
“NSU Police have secured the NSU campus. Counseling is being made available for any student in need of services.”
The US has suffered at least 456 mass shootings so far this year, according to the Gun Violence Archive. Both the non-profit and CNN define mass shootings as incidents in which four or more people are shot, excluding the shooter.
CNN’s Holly Yan contributed to this report.