Lionel Messi-led Argentina’s loss to Saudi Arabia is up there with the biggest upsets in tournament history.
But what have been some of the other major giant killings through the years?
CAMEROON 1-0 ARGENTINA (1990)
Much like Messi, Diego Maradona was also embarrassed in their opening World Cup match.
In the 1990 edition of the tournament, a little-known Cameroon team defeated Argentina, although the South American side did recover to reach the final in Italy.
SENEGAL 1-0 FRANCE (2002)
France were World Cup champions when they lost to African underdogs Senegals at the start of the 2002 World Cup.
France ended up exiting in the group stage. Senegal went on to reach the quarterfinals, just as Cameroon did in 1990.
SOUTH KOREA 2-1 ITALY (2002)
The 2002 World Cup threw up another eye-opener when co-host South Korea made a run to the semifinals.
South Korea had beaten Portugal in the group stage but bettered that upset with a 2-1 win in extra time over Italy in the last 16. Italy was a three-time champion at the time while South Korea had never won a World Cup game before the tournament.
UNITED STATES 1-0 ENGLAND (1950)
Haitian-born Joe Gaetjens was the unlikely hero for the United States in a 1-0 upset over England at 1950 World Cup in Brazil.
The American team was basically made up of part-timers and the result reverberated across the game as one of the first big World Cup upsets.